Objectives To date, many artificial intelligence (AI) systems have been developed in
healthcare, but adoption has been limited. This may be due to inappropriate or incomplete …

OBJECTIVES This study aimed to identify clinical features associated with premature
mortality in a large contemporary cohort of adults with type 1 diabetes. RESEARCH DESIGN …

Metabolite associations with insulin resistance were studied in 7,098 young Finns (age 31±3
years; 52% women) to elucidate underlying metabolic pathways. Insulin resistance was …

Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes
and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or …

Background—Long-term physical inactivity seems to cause many health problems. We
studied whether persistent physical activity compared with inactivity has a global effect on …

OBJECTIVE Metabolite predictors of deteriorating glucose tolerance may elucidate the
pathogenesis of type 2 diabetes. We investigated associations of circulating metabolites …

The majority of the heritability of coronary artery disease (CAD) remains unexplained,
despite recent successes of genome-wide association studies (GWAS) in identifying novel …

Subtle metabolic changes precede and accompany chronic vascular complications, which
are the primary causes of premature death in diabetes. To obtain a multimetabolite …

Background Pregnancy triggers well-known alterations in maternal glucose and lipid
balance but its overall effects on systemic metabolism remain incompletely understood …

The metabolically connected triad of obesity, diabetes, and cardiovascular diseases is a
major public health threat, and is expected to worsen due to the global shift toward energy …