Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b …
Background Sjögren's syndrome is an autoimmune disease characterised by dry eyes and
mouth, systemic features, and reduced quality of life. There are no disease-modifying …
mouth, systemic features, and reduced quality of life. There are no disease-modifying …
Raynaud's phenomenon in mixed connective tissue disease
T Grader-Beck, FM Wigley - Rheumatic Disease Clinics, 2005 - rheumatic.theclinics.com
When Sharp and colleagues [1] first identified the mixed connective tissue disease (MCTD)
phenotype, it was based solely on serologic evidence that was characterized by high-titer …
phenotype, it was based solely on serologic evidence that was characterized by high-titer …
Ocular and systemic morbidity in a longitudinal cohort of Sjögren's syndrome
EK Akpek, P Mathews, S Hahn, M Hessen, J Kim… - Ophthalmology, 2015 - Elsevier
Purpose To report vision-threatening ocular manifestations of primary Sjögren's syndrome
(SS). Design Retrospective review. Participants Consecutive patients evaluated at an SS …
(SS). Design Retrospective review. Participants Consecutive patients evaluated at an SS …
Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics
LJ Appleman, D Tzachanis, T Grader-Beck… - Journal of molecular …, 2001 - Springer
Tolerance in vivo and its in vitro counterpart, anergy, are defined as the state in which helper
T lymphocytes are alive but incapable of producing IL-2 and expanding in response to …
T lymphocytes are alive but incapable of producing IL-2 and expanding in response to …
Ocular complications of primary Sjögren syndrome in men
PM Mathews, S Hahn, M Hessen, J Kim… - American journal of …, 2015 - Elsevier
Purpose To report the ocular complications of primary Sjögren syndrome (SS) in men.
Design Retrospective cohort study. Methods setting: Tertiary-care SS center. patient …
Design Retrospective cohort study. Methods setting: Tertiary-care SS center. patient …
Ultrasound‐guided biopsy of suspected salivary gland lymphoma in Sjögren's syndrome
AN Baer, T Grader‐Beck, B Antiochos… - Arthritis care & …, 2021 - Wiley Online Library
Objective To evaluate the safety and utility of core needle biopsy (CNB) for diagnosis of
salivary gland lymphoma in Sjögren's syndrome (SS). Methods We analyzed data from …
salivary gland lymphoma in Sjögren's syndrome (SS). Methods We analyzed data from …
A national survey of burnout and depression among fellows training in pulmonary and critical care medicine: a special report by the association of pulmonary and …
M Sharp, KM Burkart, MH Adelman, RW Ashton… - Chest, 2021 - Elsevier
Background The prevalence of burnout and depressive symptoms is high among physician
trainees. Research Question What is the burden of burnout and depressive symptoms …
trainees. Research Question What is the burden of burnout and depressive symptoms …
Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease
T Grader-Beck, F Boin, S Von Gunten… - Annals of the …, 2011 - ard.bmj.com
Background Glycosylation represents an important modification that regulates biological
processes in tissues relevant for disease pathogenesis in systemic sclerosis (SSc), including …
processes in tissues relevant for disease pathogenesis in systemic sclerosis (SSc), including …
cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression
T Grader-Beck, AAFL Van Puijenbroek… - Blood, The Journal …, 2003 - ashpublications.org
Cyclic adenosine monophosphate (cAMP) is a negative regulator of T-cell activation.
However, the effects of cAMP on signaling pathways that regulate cytokine production and …
However, the effects of cAMP on signaling pathways that regulate cytokine production and …
A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome
J Kim, D Sun, R Ozl, T Grader‐beck… - The …, 2016 - Wiley Online Library
Objectives/Hypothesis To validate a technique and outcomes of labial minor salivary gland
biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design Prospective …
biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design Prospective …