User profiles for "author:James Thornton"

James Thornton

- Verified email at apple.com - Cited by 513

James M. Thornton

- Verified email at unibe.ch - Cited by 428

Climate changes and their elevational patterns in the mountains of the world

NC Pepin, E Arnone, A Gobiet, K Haslinger… - Reviews of …, 2022 - Wiley Online Library
Quantifying rates of climate change in mountain regions is of considerable interest, not least
because mountains are viewed as climate “hotspots” where change can anticipate or …

How does Lin28 let-7 control development and disease?

JE Thornton, RI Gregory - Trends in cell biology, 2012 - cell.com
One of the most ancient and highly conserved microRNAs (miRNAs), the let-7 family, has
gained notoriety owing to its regulation of stem cell differentiation and essential role in …

Direct and indirect cost of managing Alzheimer's disease and related dementias in the United States

A Deb, JD Thornton, U Sambamoorthi… - Expert review of …, 2017 - Taylor & Francis
Introduction: Care of individuals with Alzheimer's Disease and Related Dementias (ADRD)
poses special challenges. As the disease progresses, individuals with ADRD require …

Networking named content

V Jacobson, DK Smetters, JD Thornton… - Proceedings of the 5th …, 2009 - dl.acm.org
Network use has evolved to be dominated by content distribution and retrieval, while
networking technology still speaks only of connections between hosts. Accessing content …

[HTML][HTML] The Lin28/let-7 axis regulates glucose metabolism

H Zhu, N Shyh-Chang, AV Segrè, G Shinoda, SP Shah… - Cell, 2011 - cell.com
The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while
the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We …

EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent

K Xu, ZJ Wu, AC Groner, HH He, C Cai, RT Lis, X Wu… - Science, 2012 - science.org
Epigenetic regulators represent a promising new class of therapeutic targets for cancer.
Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2) …

[BOOK][B] Sport, culture and society: an introduction

G Jarvie, J Thornton, H Mackie - 2013 - taylorfrancis.com
It is impossible to fully understand contemporary society and culture without acknowledging
the place of sport. Sport is part of our social and cultural fabric, possessing a social and …

[HTML][HTML] Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms

E Piskounova, C Polytarchou, JE Thornton… - Cell, 2011 - cell.com
Summary Lin28A and Lin28B selectively block the expression of let-7 microRNAs and
function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase …

Diffusion schrödinger bridge with applications to score-based generative modeling

V De Bortoli, J Thornton, J Heng… - Advances in Neural …, 2021 - proceedings.neurips.cc
Progressively applying Gaussian noise transforms complex data distributions to
approximately Gaussian. Reversing this dynamic defines a generative model. When the …

VoCCN: voice-over content-centric networks

V Jacobson, DK Smetters, NH Briggs… - Proceedings of the …, 2009 - dl.acm.org
A variety of proposals call for a new Internet architecture focused on retrieving content by
name, but it has not been clear that any of these approaches are general enough to support …