Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

We present in this work a new calculation of the standard-model benchmark value for the
effective number of neutrinos, $ N_ {\rm eff}^{\rm SM} $, that quantifies the cosmological …

Abstract The magisterial Oxford History of English Literature is here reissued in its entirety,
so that readers can collect any volumes that they missed on first publication, and new …

We revisit and quantify in this work several aspects of Standard Model physics at finite
temperature that drive the theoretical value of the cosmological parameter, the effective …

The structural diversity of natural products offers unique opportunities for drug discovery, but
challenges associated with their isolation and screening can hinder the identification of drug …

JAW Bennett, Poetry of the Passion: Studies in Twelve Centuries of English Verse - PhilPapers
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This personal account focuses on synthesis of polyhydroxylated piperidines, a subset of
compounds within the iminosugar family. Cyclisations to form the piperidine ring include …

Molecular glues stabilize interactions between E3 ligases and novel substrates to promote
substrate degradation, thereby facilitating the inhibition of traditionally “undruggable” protein …

Membrane proteins are challenging to analyze by native mass spectrometry (MS) as their
hydrophobic nature typically requires stabilization in detergent micelles that are removed …

Synaptotagmin-1 (Syt-1) is a calcium sensing protein that is resident in synaptic vesicles. It is
well established that Syt-1 is essential for fast and synchronous neurotransmitter release …