User profiles for "author:Biplav Shrestha"

Biplav Shrestha

- Verified email at bblumberg.org - Cited by 284

Biplav Shrestha

- Verified email at nyayahealthnepal.org - Cited by 42

[HTML][HTML] Marine rare actinobacteria: isolation, characterization, and strategies for harnessing bioactive compounds

D Dhakal, AR Pokhrel, B Shrestha… - Frontiers in microbiology, 2017 - frontiersin.org
Actinobacteria are prolific producers of thousands of biologically active natural compounds
with diverse activities. More than half of these bioactive compounds have been isolated from …

[HTML][HTML] Combinatorial approach for improved cyanidin 3-O-glucoside production in Escherichia coli

B Shrestha, RP Pandey, S Darsandhari, P Parajuli… - Microbial Cell …, 2019 - Springer
Background Multi-monocistronic and multi-variate vectors were designed, built, and tested
for the improved production of cyanidin 3-O-glucoside (C3G) in Escherichia coli BL21 (DE3) …

[HTML][HTML] Design and implementation of an affordable, public sector electronic medical record in rural Nepal

A Raut, C Yarbrough, V Singh, B Gauchan… - Journal of Innovation …, 2017 - ncbi.nlm.nih.gov
Discussion Over the course of 18 months, we were able to develop, deploy and iterate upon
the electronic medical record, and then deploy the refined product at an additional facility …

Enhanced production of nargenicin A1 and creation of a novel derivative using a synthetic biology platform

D Dhakal, AK Chaudhary, JS Yi, AR Pokhrel… - Applied microbiology …, 2016 - Springer
Nargenicin A1, an antibacterial produced by Nocardia sp. CS682 (KCTC 11297BP),
demonstrates effective activity against various Gram-positive bacteria. Hence, we attempted …

Characterization of regioselective flavonoid O-methyltransferase from the Streptomyces sp. KCTC 0041BP

S Darsandhari, D Dhakal, B Shrestha, P Parajuli… - Enzyme and microbial …, 2018 - Elsevier
A flavonoid comprises polyphenol compounds with pronounced antiviral, antioxidant,
anticarcinogenic, and anti-inflammatory effects. The flavonoid modification by methylation …

Effectiveness of an educational intervention in improving healthcare workers' knowledge of early recognition, diagnosis and management of rheumatic fever and …

N Bhatt, A Karki, B Shrestha, A Singh, LB Rawal… - BMJ open, 2022 - bmjopen.bmj.com
Objectives Rheumatic fever (RF) and rheumatic heart disease (RHD) remain among the
major heart problems among children in Nepal. Although these conditions are preventable …

Engineering Streptomyces peucetius for Doxorubicin and Daunorubicin Biosynthesis

B Shrestha, AR Pokhrel, S Darsandhari… - … from Microbes: The …, 2019 - Springer
Doxorubicin and daunorubicin are notable members of the type II polyketide synthase family
and clinically important cancer chemotherapeutic agents and are produced by a mutant …

[HTML][HTML] Biosynthesis of natural and non-natural genistein glycosides

P Parajuli, RP Pandey, TTH Nguyen, B Shrestha… - RSC …, 2017 - pubs.rsc.org
Genistein is the principal isoflavone constituent of soybean. It has attracted more attention
than other plant polyphenols because of its significant affinity with medical interests. Herein …

Enzymatic synthesis of novel quercetin sialyllactoside derivatives

S Darsandhari, JY Bae, B Shrestha… - Natural product …, 2019 - Taylor & Francis
Quercetin and its derivatives are important flavonols that show diverse biological activity,
such as antioxidant, anticarcinogenic, anti-inflammatory, and antiviral activities. Adding …

Biosynthesis of bioactive tamarixetin in recombinant Escherichia coli

S Darsandhari, D Dhakal, B Shrestha… - Biotechnology and …, 2021 - Wiley Online Library
Tamarixetin, a monomethylated derivative of quercetin, has been reported to possess many
important biological activities. In the present study, a whole cell biotransformation system …