User profiles for "author:Arun Radhakrishnan"

Arun Radhakrishnan

Professor, University of Texas Southwestern Medical Center
Verified email at utsouthwestern.edu
Cited by 7331

[HTML][HTML] Condensed complexes of cholesterol and phospholipids

HM McConnell, A Radhakrishnan - Biochimica et Biophysica Acta (BBA) …, 2003 - Elsevier
There is overwhelming evidence that lipid bilayer regions of animal cell membranes are in a
liquid state. Quantitative models of these bilayer regions must then be models of liquids …

Retrospective on cholesterol homeostasis: the central role of scap

MS Brown, A Radhakrishnan… - Annual review of …, 2018 - annualreviews.org
Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

Can pain be managed through the Internet? A systematic review of randomized controlled trials

JL Bender, A Radhakrishnan, C Diorio, M Englesakis… - Pain®, 2011 - Elsevier
Given the increasing penetration and health care related use of the Internet, we examined
the evidence on the impact of Internet-based interventions on pain. A search of Medline …

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

A Radhakrishnan, Y Ikeda, HJ Kwon… - Proceedings of the …, 2007 - National Acad Sciences
Cholesterol synthesis in animals is controlled by the regulated transport of sterol regulatory
element-binding proteins (SREBPs) from the endoplasmic reticulum to the Golgi, where the …

[PDF][PDF] Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

A Radhakrishnan, JL Goldstein, JG McDonald… - Cell metabolism, 2008 - cell.com
Animal cells control their membrane lipid composition within narrow limits, but the sensing
mechanisms underlying this control are largely unknown. Recent studies disclosed a protein …

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

RE Infante, ML Wang… - Proceedings of the …, 2008 - National Acad Sciences
Egress of lipoprotein-derived cholesterol from lysosomes requires two lysosomal proteins,
polytopic membrane-bound Niemann–Pick C1 (NPC1) and soluble Niemann–Pick C2 …

[PDF][PDF] Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

A Radhakrishnan, LP Sun, HJ Kwon, MS Brown… - Molecular cell, 2004 - cell.com
Mammalian cells control their membrane composition by regulating the vesicular transport of
membrane-bound sterol regulatory element binding proteins (SREBPs) from endoplasmic …

[HTML][HTML] Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

A Das, MS Brown, DD Anderson, JL Goldstein… - elife, 2014 - elifesciences.org
When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is
liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it …

[HTML][HTML] Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

RE Infante, A Radhakrishnan, L Abi-Mosleh… - Journal of Biological …, 2008 - ASBMB
Defects in Niemann-Pick, Type C-1 protein (NPC1) cause cholesterol, sphingolipids,
phospholipids, and glycolipids to accumulate in lysosomes of liver, spleen, and brain. In …

Condensed complexes, rafts, and the chemical activity of cholesterol in membranes

A Radhakrishnan, TG Anderson… - Proceedings of the …, 2000 - National Acad Sciences
Epifluorescence microscopy studies of mixtures of phospholipids and cholesterol at the air–
water interface often exhibit coexisting liquid phases. The properties of these liquids point to …