User profiles for "author:Arun Radhakrishnan"
Arun RadhakrishnanProfessor, University of Texas Southwestern Medical Center Verified email at utsouthwestern.edu Cited by 7331 |
[HTML][HTML] Condensed complexes of cholesterol and phospholipids
HM McConnell, A Radhakrishnan - Biochimica et Biophysica Acta (BBA) …, 2003 - Elsevier
There is overwhelming evidence that lipid bilayer regions of animal cell membranes are in a
liquid state. Quantitative models of these bilayer regions must then be models of liquids …
liquid state. Quantitative models of these bilayer regions must then be models of liquids …
Retrospective on cholesterol homeostasis: the central role of scap
MS Brown, A Radhakrishnan… - Annual review of …, 2018 - annualreviews.org
Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …
Can pain be managed through the Internet? A systematic review of randomized controlled trials
JL Bender, A Radhakrishnan, C Diorio, M Englesakis… - Pain®, 2011 - Elsevier
Given the increasing penetration and health care related use of the Internet, we examined
the evidence on the impact of Internet-based interventions on pain. A search of Medline …
the evidence on the impact of Internet-based interventions on pain. A search of Medline …
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig
A Radhakrishnan, Y Ikeda, HJ Kwon… - Proceedings of the …, 2007 - National Acad Sciences
Cholesterol synthesis in animals is controlled by the regulated transport of sterol regulatory
element-binding proteins (SREBPs) from the endoplasmic reticulum to the Golgi, where the …
element-binding proteins (SREBPs) from the endoplasmic reticulum to the Golgi, where the …
[PDF][PDF] Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance
A Radhakrishnan, JL Goldstein, JG McDonald… - Cell metabolism, 2008 - cell.com
Animal cells control their membrane lipid composition within narrow limits, but the sensing
mechanisms underlying this control are largely unknown. Recent studies disclosed a protein …
mechanisms underlying this control are largely unknown. Recent studies disclosed a protein …
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
RE Infante, ML Wang… - Proceedings of the …, 2008 - National Acad Sciences
Egress of lipoprotein-derived cholesterol from lysosomes requires two lysosomal proteins,
polytopic membrane-bound Niemann–Pick C1 (NPC1) and soluble Niemann–Pick C2 …
polytopic membrane-bound Niemann–Pick C1 (NPC1) and soluble Niemann–Pick C2 …
[PDF][PDF] Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain
A Radhakrishnan, LP Sun, HJ Kwon, MS Brown… - Molecular cell, 2004 - cell.com
Mammalian cells control their membrane composition by regulating the vesicular transport of
membrane-bound sterol regulatory element binding proteins (SREBPs) from endoplasmic …
membrane-bound sterol regulatory element binding proteins (SREBPs) from endoplasmic …
[HTML][HTML] Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is
liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it …
liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it …
[HTML][HTML] Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop
RE Infante, A Radhakrishnan, L Abi-Mosleh… - Journal of Biological …, 2008 - ASBMB
Defects in Niemann-Pick, Type C-1 protein (NPC1) cause cholesterol, sphingolipids,
phospholipids, and glycolipids to accumulate in lysosomes of liver, spleen, and brain. In …
phospholipids, and glycolipids to accumulate in lysosomes of liver, spleen, and brain. In …
Condensed complexes, rafts, and the chemical activity of cholesterol in membranes
A Radhakrishnan, TG Anderson… - Proceedings of the …, 2000 - National Acad Sciences
Epifluorescence microscopy studies of mixtures of phospholipids and cholesterol at the air–
water interface often exhibit coexisting liquid phases. The properties of these liquids point to …
water interface often exhibit coexisting liquid phases. The properties of these liquids point to …