Information technology has radically changed the way that many people work and think. Over the years, technology has touched a new acme and now it is not confined to developed countries. Developing countries such as India have kept pace with the world in modern technology. Healthcare professionals can no longer ignore the application of information technology to healthcare because they are key to e-health. This study was conducted to enlighten the perspective and implications of computers among healthcare professionals, with the objective to assess the knowledge, use, and need of computers among healthcare professionals. A cross-sectional study of 240 healthcare professionals, including doctors, nurses, lab technicians, and pharmacists, was conducted. Each participant was interviewed using a pretested, semistructured format. Of 240 healthcare professionals, 57.91% were knowledgeable about computers. Of them, 22.08% had extensive knowledge and 35.83% had partial knowledge. Computer knowledge was greater among the age group 20-25 years (high knowledge-43.33% and partial knowledge-46.66%). Of 99 males, 21.21% were found to have good knowledge and 42.42% had partial knowledge. A majority of doctors and nurses used computer for study purposes. The remaining healthcare professionals used it basically for the sake of entertainment, Internet, and e-mail. A majority of all healthcare professionals (95.41%) requested computer training, which according to them would definitely help to make their future more bright and nurtured as well as to enhance their knowledge regarding computers.