Case ReportGoodpasture syndrome during the course of a Schönlein-Henoch purpura☆,☆☆
Section snippets
Case report
A 69-year-old patient had undergone surgery 2 months before admission to our department. The patient had been a smoker up to 2 months before admission, was hypertensive on medical treatment, and had a past medical history of bronchogenic squamous cell carcinoma in the right upper lobe (4.5 cm in diameter, infiltrating parietal pleura, without hilar or mediastinal lymph node involvement). A superior and medial bilobectomy had been performed with mediastinal lymphadenectomy and section of the
Discussion
The diagnosis of Goodpasture syndrome requires the demonstration of anti-GBM circulating antibodies and a characteristic linear pattern on direct immunofluorescence, which is usually IgG, but occasionally non-IgG antibodies can be present or both.4 Lung neoplasms have been noted among the precipitating factors that can trigger Schönlein-Henoch purpura.5 In the present case, although we did not have pathology samples of the pulmonary lesions, the presence of glomerulonephritis with linear IgA
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Cited by (17)
Binding Truths: Atypical Anti−Glomerular Basement Membrane Disease Mediated by IgA Anti−Glomerular Basement Membrane Antibodies Targeting the α1 Chain of Type IV Collagen
2019, Kidney International ReportsCitation Excerpt :No binding was found, suggesting that the antibody targeting the GBM was not due to formation of IgA−fibronectin complexes (data not shown). Interestingly, in 5 of 14 case reports, the patients had concurrent autoimmune or alternative renal diseases: Henoch–Schonlein purpura/IgA nephropathy,8,19 Crohn's disease,9 systemic lupus erythematosus,13 autoimmune bullous dermatitis,14 and thin basement membrane disease.12 Whether the coexistence of the conditions could facilitate the development of anti-GBM disease is an interesting hypothesis that remains to be proved.
The pulmonary-renal syndrome: A diagnostic and therapeutic emergency for the internist and the intensivist
2013, Revue de Medecine InterneIgA mediated anti-glomerular basement membrane disease with associated circulating anti-neutrophil cytoplasm antibodies
2024, Journal of NephropathologyGoodpasture syndrome and anti-glomerular basement membrane disease
2023, Clinical and Experimental Rheumatology
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Address reprint requests to Luis Carreras, MD, PhD, Scio de Nefrología, Hospital Princeps d'Espanya, CSUB, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. E-mail: [email protected]
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