Traditional boundaries among basic research, clinical research and patient-oriented research are yielding to a single, continuous, bidirectional spectrum commonly termed 'translational research' or 'translational medicine.' These encompass (i) the definition of guidelines for drug development or for the identification and validation of clinically relevant biomarkers; (ii) experimental nonhuman and nonclinical studies conducted with the intent of developing principles for the discovery of new therapeutic strategies; (iii) clinical investigations that provide a biological foundation for the development of improved therapies; (iv) any clinical trial initiated in accordance with the above goals; and (v) basic science studies that define the biological effects of therapeutics in humans. Although these goals are essentially no different from those of traditional academic clinical research, translational research emphasizes strategies to expedite their successful implementation. Unfortunately, several barriers that delay this process need to be surmounted to make translational research more than just an interesting concept.
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References
Berg, P., Goldstein, L., Marincola, E., Moore, M.T. & Wilson, K. ASCB Newsletter 27, 6 (2004).
Wadman, M. Nature 431, 886 (2004).
Heffler, S. et al. Health Aff. (Millwood) published online 23 February 2005 (10.1377/hlthaff.W5.74).
Jemal, A. et al. CA Cancer J. Clin. 54, 8–29 (2004).
Snyderman, R. JAMA 291, 882–883 (2004).
Parks, M.R. & Disis, M.L. J. Transl. Med. 2, 28 (2004).
Martin, J.B. & Kasper, D.L. N. Engl. J. Med. 343, 1646–1649 (2000).
AAMC Task Force on Financial Conflicts of Interest in Clinical Research. Acad. Med. 78, 237–245 (2003).
Snyderman, R. J. Clin. Invest. 114, 1169–1173 (2004).
Arteaga, C.L. & Baselga, J. Clin. Cancer Res. 9, 1579–1589 (2003).
Roadblocks to cancer cures. Nat. Med. 10, 1003 (2004).
Kluft, C. Maturitas 47, 293–298 (2004).
Conley, B.A. & Taube, S.E. Dis. Markers 20, 35–43 (2004).
Hammond, M.E. & Taube, S.E. Semin. Oncol. 29, 213–221 (2002).
Monsurro', V. et al. Sem. Cancer Biol. 13, 473–480 (2003).
Lotze, M.T. et al. J. Immunother. 28, 79–119 (2005).
Lehmann, F., Lacombe, D., Therasse, P. & Eggermont, A.M. J. Transl. Med. 1, 2 (2003).
Glass, A.G. et al. Clin. Cancer Res. 7, 1843–1849 (2001).
Schechter, A.N., Perlman, R.L. & Rettig, R.A. Perspect. Biol. Med. 47, 476–486 (2004).
Rees, J. Science 296, 698–700 (2002).
Bialek, W. & Botstein, D. Science 303, 788–790 (2004).
Joiner, K.A. J. Transl. Med. 3, 19 (2005).
Mintzberg, H. Harv. Bus. Rev. 59, 103–116 (1981).
Mankoff, S.P., Brander, C., Ferrone, S. & Marincola, F.M. J. Transl. Med. 2, 14 (2004).
Atkins, M.B. et al. Clin. Cancer Res. 11, 3714–3721 (2005).
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Hörig, H., Marincola, E. & Marincola, F. Obstacles and opportunities in translational research. Nat Med 11, 705–708 (2005). https://doi.org/10.1038/nm0705-705
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DOI: https://doi.org/10.1038/nm0705-705
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