Asthma diagnosis and treatmentAn audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma
Section snippets
Subjects
Adolescent and adult subjects aged 12 to 65 years with a diagnosis of asthma were enrolled in this study (Fig 1). Subjects were recruited from research volunteer databases, newspaper advertisements, and informal contacts. Inclusion criteria were the requirement to take regular ICS at a fixed dose, no exacerbation in the previous month or run-in period, not pregnant or lactating, and if of child-bearing potential, using contraception. Exclusion criteria were a diagnosis of chronic obstructive
Results
There were 110 subjects with asthma (50 men) randomized in the study. These subjects were aged between 13 and 65 years and on entry were taking a median (range) daily dose of BDP or equivalent of 500 μg (100-4000 μg per day). There were no differences in baseline characteristics between the 2 groups (Table I). By the completion of the study, 11 and 9 subjects in the AVRF and control groups, respectively, did not provide data in the final 12-week period of the study (Fig 1).
Discussion
This study has demonstrated that an AVRF can significantly improve adherence with ICS therapy in adult asthma. The absolute difference in adherence was large, at around 18%, and the proportion of subjects who achieved more than 80% and 90% adherence was between 2- and 3-fold higher in the subjects who had the AVRF.
References (22)
- et al.
Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma
J Allergy Clin Immunol
(2004) - et al.
Compliance of patients with asthma with an experimental aerosolized medication: implications for controlled clinical trials
J Allergy Clin Immunol
(1986) - et al.
Compliance with prescribed drug therapy in asthma
Respir Med
(1994) - et al.
Interventions to enhance patient adherence to medication prescriptions: scientific review
JAMA
(2002) A systematic review of adherence with medications for diabetes
Diabetes Care
(2004)- et al.
Interventions to improve medication adherence in schizophrenia
Am J Psychiatry
(2002) - et al.
Compliance with osteoporosis medications
Arch Int Med
(2005) Therapeutic compliance in asthma: its magnitude and implications
Eur Respir J
(1992)- et al.
Relationship of adherence to pediatric asthma morbidity among inner-city children
Pediatrics
(2002) - et al.
Corticosteroid use after hospital discharge among high-risk adult with asthma
Am J Respir Crit Care Med
(2004)
The effect of a medication alarm device for medical adherence research
J Am Optom Assoc
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Supported by a research grant from GlaxoSmithKline, UK.
Disclosure of potential conflict of interest: R. Beasley has served as a medical advisor for Nexus6 Ltd. The rest of the authors have declared that they have no conflict of interest.