Table 2

IRT model prediction for surrogate labels contributing or related to CAD

Surrogate labelsAUC (95% CI)MAE (95% CI)
ASCVD traditional risk factors
 Hyperlipidaemia0.831 (0.811 to 0.850)/
 Hypertension0.640 (0.607 to 0.673)/
 Diabetes mellitus0.659 (0.573 to 0.745)/
 Male0.988 (0.985 to 0.991)/
 Age/8.23 (7.543 to 8.914)
 Body mass index/2.593 (2.147 to 3.038)
 Smoking0.749 (0.694 to 0.804)/
 Early ASCVD family history0.691 (0.587 to 0.795)/
 HbA1C%/0.772 (0.686 to 0.859)
Inflammation and other cardiovascular markers
 Chronic inflammatory diseases0.631 (0.536 to 0.726)/
 Elevated ESR level*0.645 (0.524 to 0.766)/
 Elevated Inflammatory Markers 0.601 (0.539 to 0.663)/
 NT-proBNP>300 pg/mL0.636 (0.593 to 0.678)/
  • *The elevated level refers to the laboratory value higher than the upper bound of reporting normal range.

  • †Inflammatory markers include ESR, C reactive protein and Interleukin-6.

  • ASCVD, atherosclerotic cardiovascular diseases; AUC, area under the curve; CAD, coronary artery disease; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; HbA1C%, Hemoglobin A1C%; IRT, infrared thermography; MAE, mean absolute error; NT-proBNP, N-terminal pro-B-type natriuretic peptide.