Table 1

ChatGPT-3.5 from the paper’s online supplemental material S1 (6), chaptGPT-3.5 and GPT-4 adapted output

ChatGPT-3.5 with simple prompt (from the study6)ChatGPT-3.5 with pretraining and structured promptGPT-4 with pretraining and structured prompt
Patient 9
‘(…)the patient has a malignant brain tumour known as an astrocytoma. These tumours are typically treated with a combination of surgery, radiation therapy and chemotherapy.(…)’‘Oncological diagnosis: Glioblastoma (WHO grade IV) right precentral lesion(…)
Proposed treatment: Palliative care, supportive management.
Discussion: Considering the patient’s age, comorbidities and postoperative complications, the panel recommends a palliative approach.(…)’
‘Oncological diagnosis:
Glioblastoma (WHO grade IV) Right precentral Lobe(…)
Proposed treatment:
Due to the poor general condition and advanced age of the patient,(…)focus should be on symptomatic relief, quality of life, and palliative care.
(…)The tumour board suggests a supportive and palliative care approach(…). Regular follow-ups with palliative care and neurology teams should be established(…).’
Patient 10
‘(…)the patient likely has a grade III or IV astrocytoma.
The best adjuvant treatment for this type of tumour would likely be a combination of radiation therapy and chemotherapy with temozolomide
It is also important to note that the patient has IDH-1
wild type, which is associated with poor outcome and less response to chemotherapy and radiation therapy.’
‘Oncological diagnosis: Glioblastoma (WHO grade IV) left frontotemporal lesion
Proposed treatment: Radiotherapy and chemotherapy.
Discussion: In the case of a gross total resection of a left frontotemporal glioblastoma, the neurotumour board recommends adjuvant treatment with radiotherapy and chemotherapy.(…)Close monitoring and follow-up will be essential to assess treatment response(…)’
‘Oncological diagnosis:
Glioblastoma (WHO grade IV) left frontotemporal lobe
proposed treatment:
(…)Standard adjuvant radiotherapy and chemotherapy using temozolomide according to the STUPP protocol.(…)
(…)an unmethylated MGMT promoter suggests a less favourable response to temozolomide chemotherapy, however, given the patient’s overall good health status, adjuvant radiochemotherapy remains the standard of care.(…)’
  • MGMT, O6-methylguanine-DNA methyltransferase; IDH-1, isocitrate dehydrogenase 1; STUPP protocol, temozolomide + radiotherapy according to Roger Stupp’s regimen