Table 1

Summary of key criteria used in sepsis detection algorithms

Clinical observationqSOFA*NEWS2
Consider infection
Red Flag
NEWS3+possible infection
One from lists below
SIRS*St John sepsis algorithm
Respiration Rate³2221–24≥252521–24>20>21
O2 Saturation94–9592–93<91<91
Supplemental O2Yes>92 with supp O2
Temperature, °C35.1–36.1<35<36<36.0 or
<36.0 or
Systolic blood pressure<100101–11091–100<90<9091–100<90
Heart rate41–50<40>13091–130>90>95
Level of consciousnessGCS<13 or AMSACVPUACVPUConcern
Lactate³2.0 mmol³2.0 mmol
Glucose mg/dL>140 and <200
Fluid balanceNo urine 18+ hours or <0.5 mL/kg/hourNo urine 12–18 hours
White cell count>12 k or <4 k or band >10%>12 k or <4 k or band >10%
Creatinine mg/dL (μmol/L)Increase of 0.5 over 72 hours
Bilirubin mg/dL<2.0 and < 10.0
  • *SIRS and qSOFA have previously been included in sepsis diagnostic criteria; in this report, we focus on the use of these tools as prediction/alerting algorithms.

  • ACVPU, alert, confusion, voice, pain, unresponsive; AMS, altered mental status; GCS, Glasgow Coma Score; NEWS, National Early Warning Score; qSOFA, quick Sepsis-related Organ Failure Assessment ; SIRS, systemic inflammatory response syndrome.