Table 2

Performance of ML algorithm compared with risk-based screening

ApproachProportion of the overall patient population to be screened by each approachProportion of correctly identified undiagnosed HCV cases (precision)
To find 20.9% of undiagnosed HCV cases
 R-PWID cohort3.70%0.12%
 ML algorithm1.80%0.40%
To find 48.4% of undiagnosed HCV cases
 Birth cohort34.50%0.03%
 ML algorithm12.30%0.12%
  • HCV, hepatitis C virus; ML, machine learning; R-PWID, risk of being a person who injects drugs.