Rates of true and false-positive detection of HIV by EMR alert and individual criteria
| Alert components | Total alerts | True-positive | False-positive | Proportion of the three-criteria alert true-positives | PPV (true-positives/total alerts) (95% CI) |
| ICD or ART or HIV-1 RNA† | 1191 | 1004 | 187 | 100% (reference)** | 84.3 (82.2 to 86.4) % |
| ICD or ART | 1049 | 988 | 61 | 98.4 (97.6, 99.2) % | 94.2 (92.8 to 95.6) % |
| ICD or HIV-1 RNA | 1137 | 991 | 146 | 98.7 (98.0, 99.4) % | 87.2 (85.2 to 89.1) % |
| HIV-1 RNA or ART | 1182 | 996 | 186 | 99.2 (98.7, 99.8) % | 84.3 (82.2 to 86.3) % |
| ICD only alert | 956 | 947 | 9 | 94.3 (92.9, 95.8) % | 99.1 (98.4 to 99.7) % |
| ART only alert | 960 | 901 | 59 | 89.7 (87.9, 91.6) % | 93.9 (92.3 to 95.4) % |
| HIV-1 RNA only alert | 1078 | 937 | 141 | 93.3 (91.8, 94.9) % | 86.9 (84.9 to 88.9) % |
*The three-criteria alert is used as the standard against which combinations of criteria are measured, and the sensitivity of the three-criteria alert approached 100% (95% CI 82.4% to 100%) based on the manual chart review sample.
†ICD, International Classification of Diseases, 10th Revision.
ART, antiretroviral therapy; EMR, electronic medical record; PPV, positive predictive value.