Baseline characteristics, interventions and outcomes of study population
| MIMIC | eICU-CRD | PLAGH-ICUdb | AUMCdb | UCIHJ23db | |
| Country | USA | USA | China | Netherlands | Spain |
| ICU admissions, No | 38 508 | 132 994 | 63 515 | 20 127 | 4238 |
| Male sex, No (%) | 21 793 (56.59) | 71 983 (54.15) | 38 155 (60.07) | 12 807 (65.16) | 2730 (64.42) |
| Age, years, median (IQR) | 65.70 (52.40–77.90) | 65.00 (53.00–76.00) | 56.89 (45.89–66.77) | Not available* | 63.00 (50.00–73.00) |
| Admission type, No (%): | |||||
| Elective | 6039 (15.83) | 24 631 (18.52) | 29 398 (46.29) | 14 429 (71.69) | 179 (4.22) |
| Emergency: | 32 122 (84.17) | 108 363 (81.48) | 34 117 (53.71) | 5698 (28.31) | 4059 (95.78) |
| Via emergency department | 19 152 (49.77) | 69 077 (51.94) | 29 790 (46.90) | 2515 (12.50) | 2220 (52.38) |
| Via other (eg, ward) | 13 248 (34.40) | 39 312 (29.56) | 4327 (6.81) | 3183 (15.81) | 1839 (43.39) |
| Cardiac surgery, No (%) | 7606 (19.75) | 12 103 (9.10) | 7265 (11.44) | 7036 (34.96) | 0 (0) |
| Mechanical ventilation, | |||||
| No (%) | 19 156 (49.78) | 49 159 (36.96) | Not available† | 14 055 (69.83) | 1844 (43.51) |
| Duration—hours, median (IQR) | 19.00 (6.53–82.25) | 27.82 (11.28–74.35) | Not available† | Not available | 94.65 (28.40–256.82) |
| RRT, No (%) | 1790 (4.65) | 2154 (4.38)‡ | Not available† | 918 (4.56) | 343 (8.09) |
| Crystalloid administration, | |||||
| No (%) | 27 218 (70.74) | Not available§ | 52 165 (82.13) | 19 079 (94.79) | 1894 (44.69) |
| mL, median (IQR) | 2000 (900–3650) | Not available§ | 1500 (750–2500) | 1500 (1000–2469) | 1000 (500–1500) |
| Colloid administration, No (%) | 2587 (6.72) | Not available§ | 19 527 (30.74) | 8642 (42.94) | 217 (5.12) |
| Packed red blood cell transfusion, No (%) | 12 361 (32.12) | Not available§ | 8584 (13.51) | 5435 (27.00) | 1007 (23.76) |
| ICU length of stay, hours, median (IQR) | 50.30 (28.50–98.20) | 39.00 (21.00–71.00) | 95.01 (45.67–173.16) | 25.00 (20.00–73.00) | 93.70 (48.20–191.52) |
| ICU mortality, No (%) | 2947 (7.66) | 7618 (5.73) | 3743 (5.89) | 1929 (9.58) | 619 (14.61) |
*AUMCdb only contains age categories.
†Data not recorded in PLAGH-ICUdb.
‡Data from subset of eICU-CRD sites with reliable data regarding RRT therapy.
§Excluded due to poor data collection regarding IV fluid and PRBC administration.
ICU, intensive care unit; PRBC, packed red blood cell; RRT, renal replacement therapy.