Table 1

Summary of input variables used for the base model analysis

Variable descriptionSource
Sample size1000
Discount factor for costs and outcomes3% (95% CI 2% to 6%)WHO guidelines17
Age-specific probabilities
Age bandIncidence of breast cancerAll-cause mortality
 40–440.0012200.00168CI5 Vol X*
National Institute of Statistics and Census (INDEC), Argentina10 11
 85+0.0032040.23 153
Stage distribution of breast cancer
Stage I0.2440.1320.428MoH official figures (Argentina)
Published ‘Dr. Jose Ramon Vidal’ Hospital Data (Corrientes, Argentina)12
Stage II0.4490.2830.326
Stage III0.2310.2990.167
Stage IV0.0430.2780.080
Disease progression-transition probabilities
Stage IStage IIStage IIIStage IVCancer death
Stage I0. Social Security Institute (case study)30
Stage II0.550.220.180.05
Stage III0.220.70.09
Stage IV0.140.86
Characteristics of the tests
MammographyTelemammography (TM)
Specificity0.865 (95% CI 0.83 to 0.90)MoH official figures (Argentina)6
Private (TM centre)
Sensitivity0.78 (95% CI 0.75 to 0.90)
Uptake0.39 (95% CI 0.32 to 0.46)0.5 (95% CI 0.43 to 0.57)
Utility scores
Point estimate95% CI
Stage I0.910.314 to 1.00Pataky et al16
Stage II0.750.320 to 0.983
Stage III0.510.272 to 0.745
Stage IV0.450.203 to 0.557
Variable descriptionCost in ARSYearCost in GBPSource
Direct screening costs
Direct medical costs
 Mammography (public sector)$22792020£ 24.23Official figures (Argentina)19
 Medical consults (specialist)$4702020£ 5
 Mammography (private sector)$67212020£ 71.47Private data
 Telemammography$8102020£ 8.72
 Mammography—average$45002020£ 47.85Calculation
Set-up costs (telemammography)
 Online campaigns2019£ 10 073.08Private data
 Offline campaigns2019£ 9 258.21
 Opening a new clinic2019£ 73 500.00
 Number of tests per clinic (year)20196000
 Additional screening cost/test2019£ 16.58Calculation
 Leasing model (8-year contract)2020£ 2 250Private data
 Additional screening cost/test2020£ 0.38Calculation
Direct non-medical costs
 Distance to mammography centre2020200 kmPrivate data
 Distance to telemammography centre202050 km
 Price for transport/km2019£ 0.17Official figures (Argentina)20 21
 Average daily cost of informal care (caretaker)2019£ 11.31
 Total non-medical costs of mammography2020£ 39.39Calculation
 Total non-medical costs of telemammography2020£ 10.83Calculation
Direct treatment costs
 Stage I2018£ 21 482.39Average treatment costs: Brazil, Colombia and Mexico30
 Stage II2018£ 32 683.87
 Stage III2018£ 38 406.00
 Stage IV2018£ 44 508.32
  • *Cancer Incidence in Five Continents (CI5) Vol X report by the International Agency for Research on Cancer (IARC).

  • ARS, Argentine peso; GBP, British pound sterling; MoH, Ministry of Health.