RT Journal Article SR Electronic T1 Extension of the Unified Theory of Acceptance and Use of Technology 2 model for predicting mHealth acceptance using diabetes as an example: a cross-sectional validation study JF BMJ Health & Care Informatics JO BMJ Health Care Inform FD BMJ Publishing Group Ltd SP e100640 DO 10.1136/bmjhci-2022-100640 VO 29 IS 1 A1 Schretzlmaier, Patrik A1 Hecker, Achim A1 Ammenwerth, Elske YR 2022 UL http://informatics.bmj.com/content/29/1/e100640.abstract AB Objectives Mobile health applications are instrumental in the self-management of chronic diseases like diabetes. Technology acceptance models such as Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) have proven essential for predicting the acceptance of information technology. However, earlier research has found that the constructs “perceived disease threat” and “trust” should be added to UTAUT2 in the mHealth acceptance context. This study aims to evaluate the extended UTAUT2 model for predicting mHealth acceptance, represented by behavioral intention, using mobile diabetes applications as an example.Methods We extended UTAUT2 with the additional constructs “perceived disease threat” and “trust”. We conducted a web-based survey in German-speaking countries focusing on patients with diabetes and their relatives who have been using mobile diabetes applications for at least 3 months. We analysed 413 completed questionnaires by structural equation modelling.Results We could confirm that the newly added constructs “perceived disease threat” and “trust” indeed predict behavioural intention to use mobile diabetes applications. We could also confirm the UTAUT2 constructs “performance expectancy” and “habit” to predict behavioural intention to use mobile diabetes applications. The results show that the extended UTAUT2 model could explain 35.0% of the variance in behavioural intention.Discussion Even if UTAUT2 is well established in the information technologies sector to predict technology acceptance, our results reveal that the original UTAUT2 should be extended by “perceived disease threat” and “trust” to better predict mHealth acceptance.Conclusion Despite the newly added constructs, UTAUT2 can only partially predict mHealth acceptance. Future research should investigate additional mHealth acceptance factors, including how patients perceive trust in mHealth applications.All data relevant to the study are included in the article or uploaded as supplementary information.