PT  - JOURNAL ARTICLE
AU  - David Wong
AU  - Niels Peek
TI  - Does not compute: challenges and solutions in managing computable biomedical knowledge
AID  - 10.1136/bmjhci-2019-100123
DP  - 2020 Jul 01
TA  - BMJ Health & Care Informatics
PG  - e100123
VI  - 27
IP  - 2
4099  - http://informatics.bmj.com/content/27/2/e100123.short
4100  - http://informatics.bmj.com/content/27/2/e100123.full
SO  - BMJ Health Care Inform2020 Jul 01; 27
AB  - Computers can potentially play a key role in resolving knowledge mobilisation bottlenecks in health and care through decision support at the point of care based on computable biomedical knowledge (CBK). But the management of CBK comes with a range of significant computer science challenges. Some of these have been suitably addressed through the development of CBK methods and tools, while others require further research and development. We review the main challenges associated with creating, reasoning with and sharing CBK, and describe current state-of-the-art solutions as well as outstanding issues. We argue that a radical approach, in which all evidence generation is suitable for computation at the outset, is ultimately needed to take full advantage of CBK.