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Original research
Varying association of laboratory values with reference ranges and outcomes in critically ill patients: an analysis of data from five databases in four countries across Asia, Europe and North America

Authors

  • Haoran Xu School of Medicine, Chinese PLA General Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Louis Agha-Mir-Salim Laboratory for Computational Physiology, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USAInstitute of Medical Informatics, Charité - Universitätsmedizin Berlin (corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health), Berlin, Germany PubMed articlesGoogle scholar articles
  • Zachary O’Brien School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Dora C Huang Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Peiyao Li Global Health Drug Discovery Institute, Beijing, ChinaDepartment of Computer Science and Technology, Tsinghua University, Beijing, China PubMed articlesGoogle scholar articles
  • Josep Gómez Department of Intensive Care Medicine, Joan XXIII University Hospital in Tarragona, Tarragona, Catalunya, SpainPere Virgili Health Research Institute, Reus, Catalunya, Spain PubMed articlesGoogle scholar articles
  • Xiaoli Liu Laboratory for Computational Physiology, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USASchool of Biological Science and Medical Engineering, Beihang University, Beijing, China PubMed articlesGoogle scholar articles
  • Tongbo Liu Information Department, Chinese PLA General Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Wesley Yeung Laboratory for Computational Physiology, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USADepartment of Cardiology, National University Health System, Singapore PubMed articlesGoogle scholar articles
  • Patrick Thoral Department of Intensive Care Medicine, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Paul Elbers Department of Intensive Care Medicine, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Zhengbo Zhang Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • María Bodí Saera Department of Intensive Care Medicine, Joan XXIII University Hospital in Tarragona, Tarragona, Catalunya, SpainPere Virgili Health Research Institute, Reus, Catalunya, Spain PubMed articlesGoogle scholar articles
  • Leo Anthony Celi Laboratory for Computational Physiology, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USADivision of Pulmonary Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Louis Agha-Mir-Salim; mirsalim{at}mit.edu
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Citation

Xu H, Agha-Mir-Salim L, O’Brien Z, et al
Varying association of laboratory values with reference ranges and outcomes in critically ill patients: an analysis of data from five databases in four countries across Asia, Europe and North America
BMJ Health & Care Informatics 2021;28:e100419. doi: 10.1136/bmjhci-2021-100419

Publication history

  • Received May 27, 2021
  • Accepted September 17, 2021
  • First published October 12, 2021.
Online issue publication 
October 12, 2021

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.