| Subjects |
Includes those eligible for care from the health system Clinical topics where case finding and outcomes are measured using routine data Large number of cases Case definition will be that of usual practice Wide range of other therapies and co-morbidities Few inclusion/exclusion criteria
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| Setting |
Routine care Range of treatment pathways Comprehensive use of computerised medical records, across the care pathway Need to infer meaning from ‘messy’ routine data
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| Intervention/exposure |
Prospective (including pragmatic RCTs) and retrospective studies are possible Open label/neither clinician nor patient will be blinded May be over a long period of time That delivered as part of usual care/generally no additional visits Standard patterns of adherence, no attempts to change beyond those that are part of routine care
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| Outcome measure |
Defined from routine data Loss to follow-up of those who move out of area/out of system Avoids recall bias Can include health economic impact
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| Comparator group |
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